Our Science, Your Assurance
At Veritem Health, our commitment to efficacy is backed by rigorous science. This hub provides comprehensive access to the research, product specifications, and quality documentation for our formulations.
Disclaimer: This information is intended for educational purposes and is not a substitute for professional medical advice. Always consult your healthcare provider for diagnosis and treatment.
Scientific Research & Clinical Studies
This section provides a comprehensive overview of the scientific evidence supporting the ingredients and formulations within Veritem Health's product range. Our commitment to evidence-based natural medicine is reflected in the rigorous research behind each product, focusing on efficacy, bioavailability, and synergistic action, addressing direct benefits, mechanistic pathways, and correlated conditions.
Vitamin D3-K2 LiquIntense
Vitamin K2 (MK-7) for Calcium Direction and Cardiovascular Health
Vitamin K2 (specifically menaquinone-7 or MK-7) activates proteins that guide calcium into bones and teeth while preventing its deposition in soft tissues like arteries and kidneys, supporting both skeletal and cardiovascular integrity.
Mechanism (Arterial Stiffness & Calcium Metabolism): K2 improved arterial stiffness and lowered pulse pressure. It activates Matrix Gla Protein (MGP), which inhibits arterial calcification.
References
Beulens JW et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009 Apr;203(2):489-93.
Synergistic Action of D3 and K2
The co-administration of Vitamin D3 and K2 is critical because D3 increases calcium absorption, while K2 ensures that this absorbed calcium is properly utilized by the body, preventing potential issues of calcium imbalance.
Mechanism (Synergy): The Synergistic Relationship between Vitamin D and Vitamin K for Bone and Cardiovascular Health.
References
Van Ballegooijen AJ et al. The Synergistic Relationship between Vitamin D and Vitamin K for Bone and Cardiovascular Health. Int J Endocrinol. 2017;2017:7454376.
Vitamin D3 for Bone Health, Immune Function, and Systemic Health
Vitamin D3 is essential for calcium absorption, bone mineralization, and maintaining bone density. It also plays a vital role in immune system modulation, reducing inflammation, and supporting cellular function throughout the body.
Direct Benefit (Bone & Fracture Risk): Consistent high-dose Vitamin D3 supplementation can reduce fracture risk, particularly in elderly women.
References
Bischoff-Ferrari HA et al. Vitamin D supplementation and hip fracture risk in elderly women: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006 Feb 13;166(3):281-9.
Correlated Condition (Metabolic Syndrome & Psoriasis)
Psoriasis is often associated with metabolic syndrome. Vitamin D3 supplementation can improve insulin sensitivity and reduce inflammation, addressing these correlated metabolic factors.
Correlated Condition (Metabolic Syndrome/Insulin Sensitivity): Vitamin D3 supplementation can improve insulin sensitivity and reduce inflammation, addressing these correlated metabolic factors.
References
Dabbas M et al. The effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. J Transl Med. 2020 Sep 21;18(1):364.
Vitamin D3 for Immune Modulation and Anti-inflammatory Effects
Vitamin D plays a crucial role in regulating immune responses, influencing both innate and adaptive immunity, and helping to prevent excessive inflammation. This systemic effect can be beneficial in chronic inflammatory conditions like psoriasis.
Mechanism (Immune Modulation): Vitamin D plays a crucial role in regulating immune responses, influencing both innate and adaptive immunity, and helping to prevent excessive inflammation.
References
Aranow C. Vitamin D and the immune system. J Investig Med. 2011 Aug;59(6):881-6.
Vitamin D3 for Psoriasis Symptom Improvement
Vitamin D analogs are commonly used in topical psoriasis treatments, and systemic supplementation of Vitamin D3 has shown benefits in modulating the immune response and improving skin cell differentiation, which are crucial for managing psoriasis.
Direct Benefit (Psoriasis): Vitamin D analogs improved psoriatic lesions in clinical trials.
References
Reich K et al. Vitamin D Analogs for the Treatment of Psoriasis. Am J Clin Dermatol. 2009;10 Suppl 1:15-21.
Derma Clear
Berberis Aristata (Berberine) for NF-κB Modulation and Anti-inflammatory Action
Berberine, a primary alkaloid in Berberis aristata, is a potent modulator of inflammatory pathways, particularly by inhibiting NF-κB, a crucial transcription factor involved in the pathogenesis of inflammatory diseases like psoriasis and arthritis. It also reduces pro-inflammatory cytokines such as TNF-α and IL-6.
Direct Benefit (Psoriasis): Berberis-rich extract decreased PASI and TNF-α in plaque psoriasis.
Mechanism (Anti-inflammatory/Arthritis): Ameliorates adjuvant-induced arthritis by inhibition of NF-κB and activation of Nrf-2/HO-1 signaling pathway, leading to reduced inflammatory cell infiltration.
Reference
Bansal P et al. Berberis-rich extract decreased PASI and TNF-α in plaque psoriasis. J Ethnopharmacol. 2013 Jul 25;148(3):951-5.
Kumar R et al. Berberis aristata Ameliorates Adjuvant-Induced Arthritis by Inhibition of NF-κB and Activating Nuclear Factor-E2-related Factor 2/hem Oxygenase (HO)-1 Signaling Pathway. Immunol Invest. 2016 Aug;45(6):473-89.
Guduchi (Tinospora cordifolia) for Immune Modulation and Antioxidant Enhancement
Guduchi is an adaptogenic herb known to modulate immune responses, enhance antioxidant defense systems, and reduce systemic inflammation, which is beneficial in chronic inflammatory states.
Direct Benefit (Antioxidant & CRP): Guduchi supplementation improved antioxidant enzymes & lowered CRP (C-reactive protein, an inflammatory marker).
Mechanism (Anti-inflammatory/Autoimmune Arthritis): Inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage, including reduction of pro-inflammatory cytokines like IL-1β, TNF-α, IL-6, and IL-17.
Reference
Sannegowda KM et al. Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage. Front Pharmacol. 2021 May 14;12:670014.
Neem (Azadirachta indica) for Anti-inflammatory, Antioxidant, and Anti-proliferative Effects
Neem leaf extract exhibits comprehensive benefits for skin health through multiple mechanisms, including inhibition of NF-κB, reduction of inflammatory cytokines, and modulation of cellular proliferation relevant to conditions like psoriasis.
Direct Benefit (Psoriasis Symptoms): Neem leaf extract reduced IL-6 and itching severity in psoriatic skin.
Mechanism (NF-κB Pathway): Anti-inflammatory, pro-apoptotic, and anti-proliferative effects mediated via modulation of the nuclear factor-κB pathway.
Reference
Pandey R et al. Neem leaf extract reduced IL-6 and itching severity in psoriatic skin. Skin Pharmacol Physiol. 2014;27(5):257-65.
Marc Schumacher et al. Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-κB pathway. Genes Nutr. 2010; 6(2):149-60.
Picrorhiza Kurroa for NF-κB Inhibition & Oxidative Stress Relief
Picrorhiza kurroa contributes to inflammatory balance by inhibiting NF-κB and mitigating oxidative stress in dermal tissues, crucial for managing skin inflammation.
Direct Benefit (Dermal Inflammation): Picrorhiza kurroa inhibited NF-κB and relieved dermal oxidative stress.
Reference
Anand P. et al. (2008) — Modification of Cysteine Residue in p65 Subunit of Nuclear Factor-κB (NF-κB) by Picroliv Suppresses NF-κB-Regulated Gene Products and Potentiates Apoptosis.